CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model
Acta Pharmaceutica Sinica B
; (6): 2362-2373, 2020.
Article
in En
| WPRIM
| ID: wpr-881117
Responsible library:
WPRO
ABSTRACT
The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay.
Full text:
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Database:
WPRIM
Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2020
Document type:
Article